Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis

ObjectiveTo review short- and long-term complications associated with intraoperative rupture of benign ovarian cysts.Data SourcesThe Cochrane Central Register Controlled Trials, BIOSIS, Medline (Ovid), Web Science, ClinicalTrials.gov, Google Scholar were searched using the following terms their combinations: “spillage,” “rupture,” “leakage,” “ovarian cyst,” “teratoma,” “dermoid,” “operative,” “surgery,” “outcome.”Methods Study SelectionRandomized controlled observational studies evaluating operative outcomes surgical treatment cysts spillage compared those without included. A systematic meta-analysis Preferred Reporting Items for Systematic Reviews Meta-Analyses guidelines was performed.Tabulation, Integration, ResultsA total 28 included in qualitative analysis 12 quantitative analysis. Ovarian cyst diameter not found to be risk (relative [RR] 0.75; 95% confidence interval [CI], –0.33 1.82). Intraoperative adverse such as reoperation (RR 1.16; CI, 0.39–3.48), infertility 0.73; 0.15–3.63), transient fever 3.22; 0.83–12.51), readmission 1.00; 0.33–2.98). However, increased recurrence 3.1; 1.05–9.14). subgroup that only dermoid showed an association between postoperative chemical peritonitis 9.36; 1.20–73.28).ConclusionIntraoperative a is limited clinical outcomes. Although approach (minimally invasive vs open) should affected by concern regarding rupture, maximal efforts made prevent intra-abdominal spillage.